Glucosamine Metabolism
نویسنده
چکیده
Recent studies in this laboratory, concerned with hexosamine metabolism, required Gm-6-P,’ Galm-BP, and their respective N-acetyl derivatives. Several methods are available for the preparation of Cm-6-P, but there appears to be no previous report of Calm-6-P, although an acid-stable Galm-P has been isolated from cartilage (4). Earlier reports indicated that hexokinase and ATP would phosphorylate Cm (5, 6). The product was isolated (7) as an unstable, amorphous barium salt, and evidence was presented that this material was Gm-6-P, although it was shown to contain at least two components (8, 9). Chemical procedures for the preparation of Gm-6-P have also been described. Direct phosphorylation of Gm with polyphosphoric acid was initially used (10, 11) but yielded impure material (12). Two recent
منابع مشابه
Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy.
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